Created by Seth MacFarlane, the adult animated sitcom, Family Guy, premiered in 1999, and despite being canceled and brought back more than once, the series has become one of the longest-running television shows of all time, spanning more than two decades — and is currently in its 21st season. Full of irreverent and edgy humor that continues to push boundaries to this day, it’s unquestionable that the show has attained a level of success that few others can match.

With this in mind, it’s hard to believe that, with the exception of Mila Kunis (who got on board at the start of season 2) and Mike Henry (who stepped down after 19 seasons), the lead Family Guy voice cast has remained constant since the very first episode aired all those years ago. Despite this impressive commitment, many of the voice cast have still found time to rack up some pretty impressive acting credits. Below, we take a look at other roles you may have seen the voice cast play.

Seth MacFarlane

     Disney Media Distribution

As well as creating the series way back in the late-90s, Seth MacFarlane also voices multiple characters in the show. In fact, MacFarlane is credited with over 700 voices throughout Family Guy’s 23-year history. His most prominent voice roles on the show are Peter, Brian, and Stewie from the central Griffin family as well as their hypersexual friend Glen Quagmire. He also created and provided voices for the short-lived Family Guy spin-off The Cleveland Show and the hit animated sitcom American Dad. His work on television expands to the slightly more dramatic sci-fi series The Orville, which began as a loose parody of Star Trek. Another of his own creations, here, he plays lead protagonist captain Ed Mercer. When it comes to the big screen and feature films, MacFarlane has demonstrated his general all-encompassing talent by writing, directing, and starring in the hilarious and outrageous comedies Ted, Ted 2 and A Million Ways to Die in the West.

Alex Borstein

Alex Borstein plays the shrill voiced, strong-willed and extremely accepting (given the circumstances) matriarch of the Griffin family, Lois. Borstein is part of the esteemed alumni of the sketch comedy show MADtv alongside the likes of Aries Spears, Jordan Peele, Bobby Lee, Artie Lange, and Keegan-Michael Key. Most of her roles have been in comedies including Killers, Dinner for Schmucks and Family Guy creator and co-star’s own Ted and A Million Ways to Die in the West. Although, Borstein did appear to take on a slightly different genre direction in 2004 when appearing in the infamous Halle Berry Catwoman flick as Sally, the best friend of Berry’s Patience Phillips character.

Mila Kunis

     Cross Creek Pictures

The only member of the Griffin family not to be voiced by the same actor since first airing, Meg Griffin has been played by Mila Kunis since season 2, after the original actor, Lacey Chabert, chose to leave. After finding success as a teen on the shows Family Guy and That 70s Show in the late-90s and early-00s, Kunis has gone from height to height, becoming one of Hollywood’s biggest and most recognizable stars. Her filmography consists of a plethora of commercial and critical hits ranging from comedies like Friends with Benefits and Bad Moms to more dramatic affairs like Black Swan and the recent Netflix hit Luckiest Girl Alive. As she continues to strive in the world of movies, Kunis, like the rest of the Family Guy cast, seems to remain ever committed to the animated comedy sitcom as it continues to find new ways to entertain (and outrage).

Seth Green

     Paramount Pictures

Seth Green plays the Griffin family’s socially awkward teenage son Chris. Green is a highly prolific actor who has been working since the tender age of 7. He graduated from supporting roles in movies like Can’t Buy Me Love and My Stepmother is an Alien in the 80s to starring roles in numerous comedy movies in the 90s and 00s, including Without a Paddle and Rat Race. He also made a highly memorable appearances in the Austin Powers franchise as Doctor Evil’s moody son. It was also during this era he garnered attention for his portrayal of Oz the werewolf in the hit cult TV series Buffy the Vampire Slayer. Since then, Green has worked consistently both in television and film, including roles in the Netflix Original movie A Futile and Stupid Gesture and the sitcom Dads.

Patrick Warburton

     Paramount Television

Patrick Warburton plays Spooner Street’s strong spirited paraplegic police officer, Joe Swanson. No stranger to voicework, Warburton has lent his distinctive voice to multiple animated characters in the past, most notably, Kronk, the musclebound meat-head henchman to the evil Yzma in Disney’s The Emperor’s New Groove. That’s just the tip of the voice acting iceberg, however, with other credits including Buzz Lightyear in Buzz Lightyear of Star Command, Ian in Open Season, Blag in The Wild, Ken in Bee Movie, King Agamemnon in Mr. Peabody & Sherman, Pulaski in Planes: Fire & Rescue, Sheriff Bronson Stone in Scooby-Doo! Mystery Incorporated, and Mr. Barkin in Kim Possible. For those not so familiar with animations, you may recognize Warburton as Elaine’s on-off boyfriend David Puddy in Seinfeld, Jeff Bingham in Rules of Engagement or even as Lemony Snicket in A Series of Unfortunate Events TV series.

Jennifer Tilly

     Universal Pictures

Joe Swanson’s jaded wife Bonnie is voiced by Jennifer Tilly. Tilly is probably best known for appearing as Chucky’s psychotic bride in the Child’s Play Chucky franchise. Now instantly recognizable for her high-pitched, raspy voice, Tilly made her breakthrough when she appeared in 1994’s dark comedy Bullets Over Broadway, which earned her an Oscar nod for Best Supporting Actress. Her filmography has been fairly expansive, with her appearing in dozens of movies over the years including Liar Liar, Stuart Little and Haunted Mansion. When not acting, she’s made quite a name for herself on the poker circuit, having racked up winnings of over $1 million in live tournaments.

Arif Zahir

     Comedy Central

For the first 19 seasons Cleveland Brown, who is portrayed as a man of color on the show, was played by Mike Henry, who is white. In 2020, he announced on Twitter that he was stepping down from voicing the character after 21 years, stating “persons of color should play characters of color.” As a result, internet personality Arif Zahir took over the role. He is best known for his voice impressions of a plethora of celebrities and cartoon characters, which he uploads to his highly successful YouTube channel.